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STUDY17022
First in Human, Phase 1/1b, Open label, Multicenter Study of Bifunctional EGFR/TGF ß Fusion Protein BCA101 Monotherapy and in Combination Therapy in Patients with EGFR Driven Advanced Solid Tumors
The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.
Study Information
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STUDY21565
A Study of E7386 in Combination With Other Anticancer Drug in Participants With Solid Tumor (Endometrial cohort enrolling 2nd and 3rd line patients.)
To assess safety and tolerability and to determine the recommended Phase 2 dose (RP2D) of
E7386 in combination with other anticancer drug(s). To assess pharmacokinetic (PK) profile of study drug(s)
To assess efficacy (objective response rate [ORR], best overall response [BOR], disease control
rate [DCR], clinical benefit rate [CBR], progression-free survival [PFS], overall survival [OS],
and duration of response [DOR]) of E7386 in combination with other anticancer drug(s)
(Revised per Amendment 06)
Study Information
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STUDY21781
A Phase 1b Dose Escalation Study of AV-380 in Combination with Chemotherapy or Immunotherapy in Cancer Patients with Elevated GDF-15 Levels Colorectal Cancer, NSCLC, Pancreatic Cancer
To refine the dose and schedule of AV-380 and establish its adverse event (AE),
pharmacokinetic (PK), and pharmacodynamic (PD) profile in metastatic cancer patients with
cachexia and elevated GDF-15, receiving SoC chemotherapy for metastatic cancer
Study Information
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STUDY23504
A Phase 2, Randomized Study to Evaluate Safety, Efficacy, and Optimal Dose of ABBV-400 in Combination with Fluorouracil, Folinic Acid, and Bevacizumab and to Evaluate Safety and Efficacy of ABBV-400 in Combination with Bevacizumab in Previously Treated Subjects with Unresectable Metastatic Colorectal Cancer
To optimize ABBV-400 dose in combination with 5-FU, folinic acid, and bevacizumab to
determine the RP3D regimen for the combination. To evaluate the efficacy as measured by OR and PFS of ABBV-400 in combination with 5-FU, folinic acid, and bevacizumab, To evaluate the safety and tolerability of ABBV-400 in combination with 5-FU, folinic acid, and bevacizumab.
Study Information
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STUDY23589
A Phase 1 Open Label Study to Evaluate the Efficacy and Safety of ABBV-400 in Select Advanced Solid Tumor Indications
To assess the efficacy of ABBV-400 in each solid tumor indication, including advanced or metastatic HCC, BTC, PDAC, ESCC, TNBC, HR+/HER2- BC and HNSCC. To characterize the safety and tolerability
of ABBV-400 as monotherapy in advanced or metastatic HCC, BTC, PDAC, ESCC, TNBC, HR+/HER2- BC, and HNSCC.
Study Information